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Schedule |
May |
| Saturday, 1 May 2021 | |||||
| Time/Result | Home | Away | Venue | ||
| 2-0 | New York | Chicago | Red Bull Arena | ||
| 3-1 | Real Salt Lake | Sporting KC | Rio Tinto Stadium | ||
| 0-0 | CF Montreal | Columbus | Inter Miami CF Stadium | ||
| 1-1 | Houston | Los Angeles FC | BBVA Stadium | ||
| 2-1 | New England | Atlanta | Gillette Stadium | ||
| 0-2 | Philadelphia | New York City FC | Talen Energy Stadium | ||
| 3-0 | Orlando City SC | FC Cincinnati | Exploria Stadium | ||
| 4-1 | FC Dallas | Portland | Toyota Stadium | ||
| 0-1 | Minnesota | Austin | Allianz Field | ||
| 4-1 | San Jose | D.C. | Earthquakes Stadium | ||
| Sunday, 2 May 2021 | |||||
| Time/Result | Home | Away | Venue | ||
| 0-0 | Nashville SC | Inter Miami CF | Nissan Stadium | ||
| 3-0 | Seattle | Los Angeles | CenturyLink Field | ||
| 0-1 | Vancouver | Colorado | Rio Tinto Stadium | ||
| Friday, 7 May 2021 | |||||
| Time/Result | Home | Away | Venue | ||
| 1-2 | Real Salt Lake | San Jose | Rio Tinto Stadium | ||
| Saturday, 8 May 2021 | |||||
| Time/Result | Home | Away | Venue | ||
| 0-2 | Chicago | Philadelphia | Soldier Field | ||
| 2-0 | New York | Toronto FC | Red Bull Arena | ||
| 3-1 | Columbus | D.C. | MAPFRE Stadium | ||
| 2-0 | Nashville SC | New England | Nissan Stadium | ||
| 2-0 | Vancouver | CF Montreal | Rio Tinto Stadium | ||
| 1-1 | FC Dallas | Houston | Toyota Stadium | ||
| 1-1 | Orlando City SC | New York City FC | Exploria Stadium | ||
| 2-1 | Los Angeles | Los Angeles FC | Dignity Health Sports Park | ||
| 3-2 | Colorado | Minnesota | Dick's Sporting Goods Park | ||
| Sunday, 9 May 2021 | |||||
| Time/Result | Home | Away | Venue | ||
| 1-1 | Inter Miami CF | Atlanta | Inter Miami CF Stadium | ||
| 1-2 | Portland | Seattle | Providence Park | ||
| 2-1 | Sporting KC | Austin | Children's Mercy Park | ||
| Wednesday, 12 May 2021 | |||||
| Time/Result | Home | Away | Venue | ||
| 2-0 | Toronto FC | Columbus | Exploria Stadium | ||
| 1-1 | Philadelphia | New England | Talen Energy Stadium | ||
| 0-2 | Inter Miami CF | CF Montreal | Inter Miami CF Stadium | ||
| 1-0 | Houston | Sporting KC | BBVA Stadium | ||
| 1-0 | Minnesota | Vancouver | Allianz Field | ||
| 0-1 | San Jose | Seattle | Earthquakes Stadium | ||
| Thursday, 13 May 2021 | |||||
| Time/Result | Home | Away | Venue | ||
| 1-0 | D.C. | Chicago | Audi Field | ||
| Saturday, 15 May 2021 | |||||
| Time/Result | Home | Away | Venue | ||
| 1-1 | New York City FC | Toronto FC | Yankee Stadium | ||
| 2-0 | Los Angeles | Austin | Dignity Health Sports Park | ||
| 1-0 | Atlanta | CF Montreal | Mercedes-Benz Stadium | ||
| 1-0 | Philadelphia | New York | Talen Energy Stadium | ||
| 1-0 | Minnesota | FC Dallas | Allianz Field | ||
| 3-1 | Colorado | Houston | Dick's Sporting Goods Park | ||
| 0-0 | Real Salt Lake | Nashville SC | Rio Tinto Stadium | ||
| 0-2 | San Jose | Portland | Earthquakes Stadium | ||
| Sunday, 16 May 2021 | |||||
| Time/Result | Home | Away | Venue | ||
| 3-0 | Sporting KC | Vancouver | Children's Mercy Park | ||
| 2-3 | FC Cincinnati | Inter Miami CF | TQL Stadium | ||
| 1-0 | New England | Columbus | Gillette Stadium | ||
| 0-1 | D.C. | Orlando City SC | Audi Field | ||
| 2-0 | Seattle | Los Angeles FC | CenturyLink Field | ||
| Saturday, 22 May 2021 | |||||
| Time/Result | Home | Away | Venue | ||
| 1-2 | CF Montreal | FC Cincinnati | Inter Miami CF Stadium | ||
| 3-0 | Portland | Los Angeles | Providence Park | ||
| 1-0 | Chicago | Inter Miami CF | Soldier Field | ||
| 1-0 | Orlando City SC | Toronto FC | Exploria Stadium | ||
| 1-2 | New York City FC | Columbus | Red Bull Arena | ||
| 2-2 | FC Dallas | Real Salt Lake | Toyota Stadium | ||
| 3-1 | New England | New York | Gillette Stadium | ||
| 2-1 | Houston | Vancouver | BBVA Stadium | ||
| 1-3 | San Jose | Sporting KC | Earthquakes Stadium | ||
| 2-1 | Los Angeles FC | Colorado | Banc of California Stadium | ||
| Sunday, 23 May 2021 | |||||
| Time/Result | Home | Away | Venue | ||
| 1-1 | Seattle | Atlanta | CenturyLink Field | ||
| 0-1 | D.C. | Philadelphia | Audi Field | ||
| 1-0 | Nashville SC | Austin | Nissan Stadium | ||
| Saturday, 29 May 2021 | |||||
| Time/Result | Home | Away | Venue | ||
| 0-1 | Chicago | CF Montreal | Soldier Field | ||
| 2-1 | New York | Orlando City SC | Red Bull Arena | ||
| 2-1 | Columbus | Toronto FC | MAPFRE Stadium | ||
| 0-1 | FC Cincinnati | New England | TQL Stadium | ||
| 2-2 | Atlanta | Nashville SC | Mercedes-Benz Stadium | ||
| 1-2 | Los Angeles FC | New York City FC | Banc of California Stadium | ||
| 1-0 | Los Angeles | San Jose | Dignity Health Sports Park | ||
| 0-3 | Inter Miami CF | D.C. | Inter Miami CF Stadium | ||
| 3-2 | Sporting KC | Houston | Children's Mercy Park | ||
| 3-0 | Colorado | FC Dallas | Dick's Sporting Goods Park | ||
| 1-1 | Real Salt Lake | Minnesota | Rio Tinto Stadium | ||
| Sunday, 30 May 2021 | |||||
| Time/Result | Home | Away | Venue | ||
| 3-0 | Philadelphia | Portland | Talen Energy Stadium | ||
| 0-0 | Seattle | Austin | CenturyLink Field | ||
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